Epicardial outgrowth inhibition causes abnormalities in myocardial layer, septation, and coronary formation, which can be partially rescued by heterospecific epicardial transplant.
The study highlights the essential role of the epicardium in normal cardiac septation, myocardialization, and coronary formation during development.
In the present study, we investigated the modulatory role of the epicardium in myocardial and coronary development. Epicardial cell tracing experiments have shown that epicardium-derived cells are the source of interstitial myocardial fibroblasts, cushion mesenchyme, and smooth muscle cells. Epicardial outgrowth inhibition studies show abnormalities of the compact myocardial layer, myocardialization of cushion tissue, looping, septation, and coronary vascular formation. Lack of epicardial spreading is partly compensated by mesothelial outgrowth over the conotruncal region. Heterospecific epicardial transplant is able to partially rescue the myocardial development, as well as septation and coronary formation.
Groot et al. (2000) studied Myocardial and coronary development. Epicardial outgrowth inhibition and heterospecific epicardial transplant was evaluated on Myocardial and coronary development abnormalities. Epicardial outgrowth inhibition causes abnormalities in myocardial layer, septation, and coronary formation, which can be partially rescued by heterospecific epicardial transplant.