Key result
CV-11974 dose-dependently suppressed angiotensin II-induced increases in cytosolic free calcium, DNA synthesis, and protein synthesis in cultured rat vascular smooth muscle cells.
Why the study?
Does CV-11974 suppress angiotensin II-induced increases in cytosolic free calcium, hyperplasia, and hypertrophy in cultured rat aortic vascular smooth muscle cells?
Does CV-11974 suppress angiotensin II-induced increases in cytosolic free calcium, hyperplasia, and hypertrophy in cultured rat aortic vascular smooth muscle cells?
CV-11974 effectively blocks AT1 receptors, preventing angiotensin II-induced calcium mobilization, hyperplasia, and hypertrophy in vascular smooth muscle cells.
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Provides mechanistic support in rat VSMCs; leaves open clinical translation for angiotensin II-mediated vascular disease.
Koh et al. (1994) studied Angiotensin II-induced cellular changes. CV-11974 vs. Angiotensin II alone was evaluated on Cytosolic free calcium concentration, DNA synthesis, and protein synthesis. CV-11974 dose-dependently suppressed angiotensin II-induced increases in cytosolic free calcium, DNA synthesis, and protein synthesis in cultured rat vascular smooth muscle cells.
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