Why the study?
Does TCV-116 reduce pressure overload-induced vascular hypertrophy and aortic impedance in abdominal aortic-banded rats?
Does TCV-116 reduce pressure overload-induced vascular hypertrophy and aortic impedance in abdominal aortic-banded rats?
In a rat model of pressure overload, a higher dose of angiotensin II receptor antagonist was required to inhibit vascular hypertrophy compared to the dose needed to inhibit left ventricular hypertrophy.
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ARBs may require higher doses for vascular than LV effects in pressure overload; leaves open translation to human dosing.
Masakazu Obayashi (1999) studied this question.
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