Key result
Clinical and genetic evaluation after sudden cardiac arrest helps identify inherited conditions, which is critical given that approximately 40% of cardiac arrests are unexplained.
Why the study?
Inherited conditions contribute to unexplained sudden cardiac arrest and sudden cardiac death, and identifying them has important ramifications for individuals and at-risk relatives.
This review highlights the importance of clinical and genetic evaluation for individuals and families following sudden cardiac arrest to identify inherited arrhythmias and cardiomyopathies.
May support post-SCA evaluation to identify inherited conditions; leaves open optimal protocols and outcome impact in prospective studies.
Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are important contributors to SCA and SCD. Identifying an inherited condition after such an event not only has important ramifications for the individual, but also for relatives who may be at risk for the familial condition. This review will provide an overview of inherited cardiovascular disorders than can predispose to SCA/SCD, review the diagnostic evaluation for an individual and/or family after an SCA/SCD, and discuss the role of genetic testing.
No takes yet. Share an insight, caveat, or question.
Harris et al. (2020) conducted a review in Sudden cardiac arrest and sudden cardiac death. Clinical and genetic evaluation was evaluated. Clinical and genetic evaluation after sudden cardiac arrest helps identify inherited conditions, which is critical given that approximately 40% of cardiac arrests are unexplained.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: