Key result
Specific inflammatory protein signatures correlate with distinct vascular status measures including PWV, AIX, and cIMT.
Why the study?
The study aimed to identify plasma protein biomarkers related to inflammation that correlate with physiological measurements of vascular function and structure in healthy individuals.
Do specific inflammatory protein signatures correlate with physiological measurements of vascular function and structure (PWV, cIMT, AIX) in young healthy adults?
Cross-Sectional (n=834)
Do specific inflammatory protein signatures correlate with physiological measurements of vascular function and structure (PWV, cIMT, AIX) in young healthy adults?
Different measures of vascular status (PWV, AIX, cIMT) correlate with distinct inflammatory protein signatures in young, healthy adults, suggesting different inflammatory mediators affect different parts of the vasculature early in life.
Distinct inflammatory signatures associate with different vascular measures in healthy young adults; hypothesis-generating and requires prospective validation.
BACKGROUND AND AIMS: We aimed to identify plasma protein biomarkers related to inflammation that correlated with physiological measurements of vascular function and structure in healthy individuals. METHODS: We used the OLINK proteomics panel, which measures 92 inflammatory proteins, in 834 young, healthy non-smokers (ages 18-26). Principal component analysis (PCA) was employed to identify patterns of proteins. The following measurements were used: pulse-wave velocity (PWV), carotid intima-media thickness (cIMT) and augmentation index (AIX). Established cardiovascular risk factors were included in multivariable models. RESULTS: PCA showed four principal components (PC 1, PC 2, PC 3, PC 4). PC 3, comprising proteins related to hemostasis, was significantly and inversely correlated with PWV. Among the proteins with the highest factor loadings on PC 3, uPA was negatively correlated with PWV in multivariable regression models. AIX was significantly correlated with PC 2, comprising inflammatory cytokines. Among the proteins with the highest factor loadings on PC 2, interleukin-6 was significantly correlated with AIX in the multivariable model. cIMT was significantly correlated with PC 4, comprising proteins related to chemotaxis. Among the proteins with the highest factor loadings on PC 4, fractalkine was significantly correlated with cIMT in the multivariable model. CONCLUSIONS: In young, healthy individuals, OLINK inflammatory proteins correlated with measures of vascular status. Each of the three measures PWV, AIX, and cIMT, which target different parts of the vasculature, correlated with its own specific protein signature, indicating that different subsets of inflammatory mediators affect different parts of the vasculature and are detectable already in young healthy adults.
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Pettersson-Pablo et al. (2020) conducted a cross-sectional in Healthy individuals (n=834). Plasma protein biomarkers (OLINK proteomics panel) was evaluated on Correlation between inflammatory protein signatures and physiological measurements of vascular function and structure (PWV, cIMT, AIX).
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