Key result
TEE-guided LAAC under local anesthesia achieves ~96% successful occlusion with low major adverse event rates.
Why the study?
General anesthesia carries disadvantages, while intracardiac echocardiography can be technically challenging for imaging during left atrial appendage closure, prompting evaluation of transesophageal echocardiography under local anesthesia.
Does percutaneous left atrial appendage closure guided by TEE under local anesthesia safely prevent ischemic stroke and major bleeding in patients with non-valvular atrial fibrillation?
Population
159 patients with non-valvular AF at high stroke/bleeding risk or with anticoagulation contraindications
Design
Observational cohort study
Follow-up
Median 522 days
Authors
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Supports TEE-guided LAAC under local anesthesia as feasible with low events; leaves open efficacy versus anticoagulation pending randomized trials.
Observational (n=159)
Does percutaneous left atrial appendage closure guided by TEE under local anesthesia safely prevent ischemic stroke and major bleeding in patients with non-valvular atrial fibrillation?
Percutaneous left atrial appendage closure guided by transesophageal echocardiography under local anesthesia appears safe and effective for stroke prevention in patients with non-valvular atrial fibrillation.
Wang et al. (2021) conducted an observational in non-valvular atrial fibrillation (AF) (n=159). Percutaneous left atrial appendage closure (LAAC) guided by TEE under local anesthesia was evaluated on Successful occlusion, periprocedural major adverse events, ischemic stroke, and major bleeding. Percutaneous LAAC guided by TEE under local anesthesia achieved a 95.6% successful occlusion rate with a 1.3% periprocedural major adverse event rate and 1.9/100 person-years ischemic stroke rate.
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