Key result
Percutaneous left atrial appendage exclusion using the Watchman device may be noninferior to long-term oral anticoagulants for stroke and mortality in eligible patients.
Why the study?
Do surgical and percutaneous LAA exclusion procedures reduce stroke and mortality compared to oral anticoagulants in patients with atrial fibrillation?
Population
Patients with atrial fibrillation (20 primary studies included from 2567 citations)
Comparison
Surgical and percutaneous left atrial appendage… vs Continued oral anticoagulants (OAC)
Design
Systematic_review
Authors
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Supports Watchman consideration in OAC-eligible AF despite risks; extends RCT data via systematic synthesis.
Systematic Review
Do surgical and percutaneous LAA exclusion procedures reduce stroke and mortality compared to oral anticoagulants in patients with atrial fibrillation?
Percutaneous LAA exclusion with the Watchman device may be noninferior to OAC for stroke prevention in eligible patients, but carries significant procedural risks, and evidence is lacking for OAC-ineligible patients.
Noelck et al. (2016) conducted a systematic review in Atrial fibrillation. Surgical and percutaneous left atrial appendage exclusion procedures vs. Oral anticoagulants (OAC) was evaluated on Stroke, mortality, and adverse effects. Percutaneous left atrial appendage exclusion using the Watchman device may be noninferior to long-term oral anticoagulants for stroke and mortality in eligible patients.
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