Key result
High triglyceride glucose index linked to ~31% higher MACE risk in hypertensive patients.
Why the study?
It was unclear whether the triglyceride glucose index has prognostic value for major adverse cardiovascular events among high-risk Chinese hypertensive patients.
Does a high Triglyceride Glucose (TyG) index predict major adverse cardiovascular events in high-risk Chinese hypertensive patients?
Cohort (n=2,250)
Yes
Does a high Triglyceride Glucose (TyG) index predict major adverse cardiovascular events in high-risk Chinese hypertensive patients?
A high Triglyceride Glucose (TyG) index is an independent predictor of major adverse cardiovascular events in high-risk hypertensive patients, particularly in males and those aged ≤65 years.
We conducted a longitudinal study (from February 2017 to July 2017) to explore whether the triglyceride glucose index (TyG) index has a prognostic value for major adverse cardiovascular events (MACE) among high-risk Chinese hypertensives. The study population were from 6 districts of Tianjin, China. Finally, a total of 2250 patients were enrolled in this 3.5 year cohort study. The patients were divided into two groups according to the cut-off value of the TyG index: Low-TyG group (n = 901, TyG ≤ 8.87), High-TyG group (n = 1349, TyG > 8.87). Univariate and multivariate Cox regression analyses were used to estimate the relationship between the TyG and MACE. In multivariate cox regression analyses, the hazard ratio (HR) (95% confidence interval (CI)) of the high-TyG group was 1.313 (1.010, 1.708) compared with the low-TyG group. In those with an age ≤65 years and male subgroups, the prediction value of TyG was higher, and the risk of occurrence of MACE greater after adjusting other risk factors. The TyG index is an indicator to predict the development of MACE in hypertensive patients.
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Zhang et al. (2022) conducted a cohort in Hypertension (n=2,250). High triglyceride glucose (TyG) index (> 8.87) vs. Low TyG index (≤ 8.87) was evaluated on Major adverse cardiovascular events (MACE) (HR 1.313, 95% CI 1.010-1.708). A high triglyceride glucose index (>8.87) was associated with an increased risk of major adverse cardiovascular events compared to a low index in hypertensive patients (HR 1.313; 95% CI 1.010-1.708).
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