Key result
Inoculation with human adenovirus-37 significantly increased visceral and total body fat (P<0.001) and reduced serum triglycerides (P<0.0001) in chickens compared with controls.
Why the study?
Does inoculation with human adenoviruses (Ad-2, Ad-31, Ad-37) increase adiposity and alter serum lipids in chickens and 3T3-L1 cells?
Population
Chickens inoculated at age 3 weeks, and 3T3-L1 cells in vitro
Comparison
Inoculation with human Ad-2, Ad-31, or Ad-37 vs Inoculation with media (control)
Design
Preclinical
Follow-up
3.5 weeks
Authors
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Ad-37 increases adiposity in chickens; extends Ad-36 findings but leaves human relevance open.
Does inoculation with human adenoviruses (Ad-2, Ad-31, Ad-37) increase adiposity and alter serum lipids in chickens and 3T3-L1 cells?
p-value: p=<0.001
Ad-37 is identified as another human adenovirus that increases adiposity and alters serum lipids in an animal model, expanding the link between viral infection and obesity.
Whigham et al. (2005) studied Adiposity. Human adenoviruses (Ad-2, Ad-31, Ad-37) vs. Media (control) was evaluated on Visceral fat and total body fat (p=<0.001). Inoculation with human adenovirus-37 significantly increased visceral and total body fat (P<0.001) and reduced serum triglycerides (P<0.0001) in chickens compared with controls.
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