What question did this study set out to answer?

To determine whether infection with the avian adenovirus SMAM-1 or a serologically related virus occurs in humans and associates with obesity and altered lipid profiles.

September 1, 1997Obesity ResearchOpen Access

Association of Adenovirus Infection with Human Obesity

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Authors

NDNikhil V. DhurandharTexas Tech University PKPushpa R. KulkarniInstitute of Chemical Technology SAS. M. AjinkyaBombay Veterinary College

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Implication

Cross-sectional screening reveals higher body mass index alongside paradoxical lipid reduction in individuals with obesity, suggesting an adenoviral etiology in metabolic disease.

Key Points

To determine whether infection with the avian adenovirus SMAM-1 or a serologically related virus occurs in humans and associates with obesity and altered lipid profiles.
Screened serum samples from N=52 individuals with obesity in Bombay, India, for antibodies against SMAM-1 using the agar gel precipitation test (AGPT).
Compared body weight, body mass index (BMI), serum cholesterol, and serum triglycerides between antibody-positive (P-AGPT, n=10) and antibody-negative (N-AGPT, n=42) groups.
Inoculated serum from antibody-positive and antibody-negative subjects into chicken embryos to evaluate the presence of transmissible viral infection.
The P-AGPT group had significantly higher body weight (95.1 ± 2.1 kg vs. 80.1 ± 0.6 kg; p < 0.02) and BMI (35.3 ± 1.5 kg/m² vs. 30.7 ± 0.6 kg/m²; p < 0.001) compared with the N-AGPT group.
Serum cholesterol was significantly lower in the P-AGPT group (4.65 mmol/L vs. 5.51 mmol/L; p < 0.02), as were serum triglycerides (1.45 mmol/L vs. 2.44 mmol/L; p < 0.001).
Inoculation of serum from two P-AGPT subjects produced macroscopic lesions typical of SMAM-1 in chicken embryos, whereas serum from N-AGPT subjects caused no lesions.

Cite This Study

Dhurandhar et al. (1997) studied this question.

synapsesocial.com/papers/6aab48edcab25ebd39477940 https://doi.org/10.1002/j.1550-8528.1997.tb00672.x

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Implication

Cross-sectional screening reveals higher body mass index alongside paradoxical lipid reduction in individuals with obesity, suggesting an adenoviral etiology in metabolic disease.

Association of Adenovirus Infection with Human Obesity

Discussion

Member takes

Implication

Key Points

Cite This Study

Association of Adenovirus Infection with Human Obesity

Discussion

Member takes

Implication

Key Points

Cite This Study

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