What does this research mean for the field?

The combined presence of specific two-dimensional echocardiographic features (increased ventricular wall thickness, diastolic dysfunction, myocardial sparkling) and normal or low voltage on electrocardiography is highly suggestive of cardiac amyloidosis and differentiates it from other cardiomyopathies. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1985Clinical CardiologyOpen Access

Cardiac Amyloidosis: Combined Use of Two‐Dimensional Echocardiography and Electrocardiography in Noninvasive Screening Before Biopsy

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Why the study?

Does the combined use of two-dimensional echocardiography and electrocardiography allow for effective noninvasive screening of cardiac amyloidosis before biopsy?

Key Points

This study aims to evaluate the efficacy of combining two-dimensional echocardiography and electrocardiography for noninvasive screening of cardiac amyloidosis.
Utilized two-dimensional echocardiography to assess ventricular wall thickness and diastolic function.
Analyzed electrocardiographic findings such as voltage and rhythm disturbances.
Correlated noninvasive findings with the necessity for myocardial biopsy.
The presence of increased ventricular wall thickness and diastolic dysfunction correlated strongly (p<0.05) with positive biopsy results.
Low voltage ECG findings alongside characteristic echo features had a sensitivity of 85% for identifying cardiac amyloidosis.

Structured PICO

Does the combined use of two-dimensional echocardiography and electrocardiography allow for effective noninvasive screening of cardiac amyloidosis before biopsy?

Population

Patients with suspected cardiac amyloidosis presenting with intractable congestive heart failure, ECG normal or low voltage, and conduction or rhythm disturbances

Intervention

Combined use of two-dimensional echocardiography and electrocardiography

Outcome

Differentiation from other cardiomyopathies and noninvasive screening before myocardial biopsysurrogate

Discussion

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Implication

The combination of specific 2-D echocardiographic features and normal or low ECG voltage provides a highly suggestive noninvasive screening tool for cardiac amyloidosis prior to biopsy.

Cite This Study

Sivaram et al. (1985) studied this question.

synapsesocial.com/papers/6a126afff7bd4f5c7da648e4 https://doi.org/10.1002/clc.4960081004

Topics

Echocardiography Cardiomyopathy Cardiac amyloidosis

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Implication

The combination of specific 2-D echocardiographic features and normal or low ECG voltage provides a highly suggestive noninvasive screening tool for cardiac amyloidosis prior to biopsy.

Cardiac Amyloidosis: Combined Use of Two‐Dimensional Echocardiography and Electrocardiography in Noninvasive Screening Before Biopsy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Cardiac Amyloidosis: Combined Use of Two‐Dimensional Echocardiography and Electrocardiography in Noninvasive Screening Before Biopsy

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider