Key result
Patient self-management of oral anticoagulant therapy with phenprocoumon improved time in the international normalized ratio target range by 8.7% (95% CI, 1.6%-15.9%).
Why the study?
Does weekly patient self-management improve time in the international normalized ratio target range in patients receiving long-term oral anticoagulant therapy compared to routine care by specialized anticoagulation clinics?
Population
341 patients aged between 18 and 75 years receiving long-term oral anticoagulant therapy (OAT)
Comparison
Weekly patient self-management of oral… vs Routine care by specialized anticoagulation…
Design
RCT, 2-step randomization procedure: first, a Zelen-design randomization to…
Authors
Loading...
Supports self-management of phenprocoumon as an effective option versus clinic care; extends prior self-management evidence to long-acting agents.
RCT (n=341)
2-step Zelen-design
Yes
Does weekly patient self-management improve time in the international normalized ratio target range in patients receiving long-term oral anticoagulant therapy compared to routine care by specialized anticoagulation clinics?
Effect estimate: 8.7% improvement (95% CI 1.6%-15.9%)
Patient self-management of oral anticoagulant therapy with long-acting phenprocoumon is at least as effective as management by specialized anticoagulation clinics in maintaining INR within the target range.
Gadisseur et al. (2003) conducted an RCT in Long-term oral anticoagulant therapy (n=341). Patient self-management of oral anticoagulant therapy vs. Routine care by specialized anticoagulation clinics was evaluated on Time in the international normalized ratio target range (8.7% improvement, 95% CI 1.6%-15.9%). Patient self-management of oral anticoagulant therapy with phenprocoumon improved time in the international normalized ratio target range by 8.7% (95% CI, 1.6%-15.9%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: