For-profit hospitals had significantly higher odds of prescribing ARNI at discharge for eligible HFrEF patients compared with not-for-profit hospitals (OR 2.53; 95% CI 1.05-6.10; P=0.04).
Observational (n=16,674)
Yes
What hospital characteristics are associated with early adoption of ARNI prescription at discharge for eligible HFrEF patients?
Early adoption of ARNI for eligible HFrEF patients was low (6.1%) and associated with few hospital characteristics, notably higher in for-profit hospitals and lower in the Western US.
Effect estimate: OR 2.53 (95% CI 1.05-6.10)
p-value: p=0.04
Background The angiotensin-receptor/neprilysin inhibitor ( ARNI ) sacubitril/valsartan reduces hospitalization and mortality for patients with heart failure with reduced ejection fraction. However, adoption of ARNI into clinical practice has been slow. Factors influencing use of ARNI have not been fully elucidated. Using data from the Get With The Guidelines-Heart Failure registry, Hospital Compare, Dartmouth Atlas, and the American Hospital Association Survey, we sought to identify hospital characteristics associated with patient-level receipt of an ARNI prescription. Methods and Results We analyzed patients with heart failure with reduced ejection fraction who were eligible for ARNI prescription (ejection fraction≤40%, no contraindications) and hospitalized from October 1, 2015 through December 31, 2016. We used logistic regression to estimate the associations between hospital characteristics and patient ARNI prescription at hospital discharge, accounting for clustering of patients within hospitals using generalized estimating equation methods and adjusting for patient-level covariates. Of 16 674 eligible hospitalizations from 210 hospitals, 1020 patients (6.1%) were prescribed ARNI at discharge. The median hospital-level proportion of patients prescribed ARNI was 3.3% (Q1, Q3: 0%, 12.6%). After adjustment for patient-level covariates, for-profit hospitals had significantly higher odds of ARNI prescription compared with not-for-profit hospitals (odds ratio, 2.53; 95% CI , 1.05-6.10; P=0.04), and hospitals located in the Western United States had lower odds of ARNI prescription compared with those in the Northeast (odds ratio, 0.33; 95% CI , 0.13-0.84; P=0.02). Conclusions Relatively few hospital characteristics were associated with ARNI prescription at hospital discharge, in contrast to what has been observed in early adoption in other disease areas. Additional evaluation of barriers to implementing new evidence into heart failure practice is needed.
Luo et al. (2019) conducted an observational in Heart failure with reduced ejection fraction (n=16,674). Hospital characteristics (for-profit status) vs. Not-for-profit status was evaluated on Patient ARNI prescription at hospital discharge (OR 2.53, 95% CI 1.05-6.10, p=0.04). For-profit hospitals had significantly higher odds of prescribing ARNI at discharge for eligible HFrEF patients compared with not-for-profit hospitals (OR 2.53; 95% CI 1.05-6.10; P=0.04).