Key result
Infection with the newly emerging influenza A/Sydney/05/97-like virus was associated with a higher frequency of ill household contacts (85% vs 71%) but did not increase clinical illness severity compared to the A/Wuhan/359/95-like strain.
Why the study?
Does infection with the newly emerging A/Sydney/05/97-like influenza variant increase illness severity compared to the A/Wuhan/359/95-like variant in children?
Population
271 children diagnosed with influenza A virus infection at two tertiary care hospitals in Houston, Texas…
Comparison
Infection with the newly emerging… vs Infection with the co-circulating…
Design
Cohort
Authors
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No increased severity observed in children; leaves open household transmission dynamics for variant surveillance.
Observational (n=271)
Yes
Does infection with the newly emerging A/Sydney/05/97-like influenza variant increase illness severity compared to the A/Wuhan/359/95-like variant in children?
Effect estimate: OR 2.6 (95% CI 1.2-5.7)
Absolute Event Rate: 85.4% vs 71.3%
p-value: p=0.02
The newly emerging A/Sydney/05/97 influenza A/H3N2 variant was not associated with increased illness severity compared to the co-circulating A/Wuhan/359/95 variant in children.
O’Donnell et al. (2003) conducted an observational in Influenza A/H3N2 virus infection (n=271). Influenza A/Sydney/05/97-like virus infection vs. Influenza A/Wuhan/359/95-like virus infection was evaluated on Ill contacts in the household (OR 2.6, 95% CI 1.2-5.7, p=0.02). Infection with the newly emerging influenza A/Sydney/05/97-like virus was associated with a higher frequency of ill household contacts (85% vs 71%) but did not increase clinical illness severity compared to the A/Wuhan/359/95-like strain.
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