Key result
Acute MI in dogs and horses linked to smaller SA/AV node cells and increased collagen.
Why the study?
The heart conduction system causes various cardiac arrhythmias, but histological and morphometrical descriptions of damaged cardiac nodes during acute myocardial infarction compared with normal tissues were needed in dogs and horses.
Does acute myocardial infarction cause histopathological and morphometrical changes in the cardiac conduction nodes of dogs and horses compared to normal hearts?
Population
Five dogs and five elderly horses that succumbed to sudden cardiac death
Comparison
Damaged cardiac nodes during acute myocardial infarction vs normal tissues
Design
Histological, morphometrical, and immunohistochemical study
Authors
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Suggests nodal fibrosis as arrhythmia substrate in veterinary post-MI cases; leaves open human conduction remodeling relevance.
Observational (n=40)
No
Does acute myocardial infarction cause histopathological and morphometrical changes in the cardiac conduction nodes of dogs and horses compared to normal hearts?
Absolute Event Rate: 47% vs 34.2%
Acute myocardial infarction induces significant fibrotic and morphometric degenerative changes in the cardiac conduction nodes of dogs and horses, providing a structural basis for post-infarction arrhythmias.
Gómez-Torres et al. (2023) conducted an observational in Acute myocardial infarction / Sudden cardiac death (n=40). Acute myocardial infarction vs. Normal hearts without a history of heart disease was evaluated on Percentage of collagen fibers inside the sinoatrial node (dogs). Acute myocardial infarction in dogs and horses was associated with a decrease in the size of sinoatrial and atrioventricular node cells and an increase in collagen fibers compared to normal hearts.
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