Key result
Ischemia abolishes papillary muscle automaticity and tension while SA and AV nodes remain highly resistant.
Population
7 sinoatrial nodes, 5 atrioventricular nodes, and 11 papillary muscles prepared from the hearts of mongrel…
Comparison
Ischemia (30 min) followed by reperfusion vs Pre-ischemic baseline
Design
Preclinical
Follow-up
30 min ischemia plus reperfusion
Authors
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Differential nodal resistance in canine ischemia cautions against clinical extrapolation; leaves open human tissue vulnerability mechanisms.
In a canine model, distal segments of the cardiac excitatory and conductive system are more vulnerable to ischemia than the sinoatrial node, and post-ischemic myocardium exhibits a loss of functional reserve.
Himori et al. (1990) studied Myocardial ischaemia. Ischaemia vs. Preischaemic baseline was evaluated on Rate of automatic rhythmical contractions (automaticity) or tension development. Ischaemia abolished automaticity and tension development in papillary muscles, whereas sinoatrial and atrioventricular nodes exhibited high resistance to the ischaemic insult.
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