Subclinical Atherosclerosis and Oxidized LDL Levels in Familial Mediterranean Fever

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Familial Mediterranean Fever (n=88). Intervention: Familial Mediterranean Fever vs. Healthy subjects. Primary outcome: Oxidized low density lipoprotein (OxLDL) levels (ng/dl) (p=0.044).

Q: What does this research mean for the field?

Patients with Familial Mediterranean Fever have significantly higher oxidized LDL levels compared to healthy controls, despite no difference in carotid intima-media thickness. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Serdal Uğurlu; Sanem Nemmezi Karaca; Yeltekin Demirel; Emire Seyahi

doi:10.7197/cmj.1131483

June 19, 2022Cumhuriyet Tıp Dergisi/Cumhuriyet Üniversitesi Tıp Fakültesi dergisiOpen Access

Subclinical Atherosclerosis and Oxidized LDL Levels in Familial Mediterranean Fever

View Full Paper

Ask AI

Bookmark

Share

Key result

Familial Mediterranean Fever is linked to ~116% higher oxidized LDL despite similar CIMT.

P=0.044
n=88

Why the study?

To investigate markers of carotid atherosclerosis and oxidized low density lipoprotein levels in patients with Familial Mediterranean Fever without cardiovascular risk factors.

Does Familial Mediterranean Fever increase subclinical atherosclerosis markers (C-IMT and OxLDL) in patients without cardiovascular risk factors?

Study Design

Type

Cross-Sectional (n=88)

Multicenter

No

Structured PICO

Does Familial Mediterranean Fever increase subclinical atherosclerosis markers (C-IMT and OxLDL) in patients without cardiovascular risk factors?

P

Population

88 subjects total: 44 patients with Familial Mediterranean Fever (FMF) in attack-free period (mean age 33.5±7.5, 56.8% female) and 44 age- and gender-matched healthy controls (mean age 33.4±7.0, 56.8% female). Excluded: clinical coronary artery disease, chronic renal disease, diabetes mellitus, hypertension, history of myocardial infarction, angina pectoris, cerebrovascular disease, dyslipidemia, metabolic syndrome, active infection, postmenopausal period, and anti-lipid drug use.

C

Comparator

Age and gender-matched healthy subjects

O

Outcome

Carotid artery intima-media thickness (C-IMT) and oxidized low density lipoprotein (OxLDL) levelssurrogate

Main Result

Absolute Event Rate: 337.48% vs 156.19%

p-value: p=0.044

Limitations

Single-centered study with a limited number of subjects
Study population was younger than other study populations
Included only patients admitted to outpatient clinics, excluding asymptomatic or mildly severe patients
Patient population was comprised of only those who admitted to the outpatient clinic controls, and did not include asymptomatic or mildly severe patients who did not admit for control.

Implication

Patients with Familial Mediterranean Fever without cardiovascular risk factors do not exhibit increased carotid intima-media thickness compared to healthy controls, despite having significantly elevated OxLDL levels.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Uğurlu et al. (2022) conducted a cross-sectional in Familial Mediterranean Fever (n=88). Familial Mediterranean Fever vs. Healthy subjects was evaluated on Oxidized low density lipoprotein (OxLDL) levels (ng/dl) (p=0.044). Patients with Familial Mediterranean Fever had significantly higher oxidized LDL levels compared to healthy controls (337.48 vs 156.19 ng/dl), despite no difference in carotid intima-media thickness.

synapsesocial.com/papers/6a1286cdc031bb6829a6cd7e https://doi.org/10.7197/cmj.1131483

View Full Paper

Ask AI

Bookmark

Share

Subclinical Atherosclerosis and Oxidized LDL Levels in Familial Mediterranean Fever

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Subclinical Atherosclerosis and Oxidized LDL Levels in Familial Mediterranean Fever

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading