Key result
Children with Familial Mediterranean Fever had normal carotid intima-media thickness but significantly decreased vitamin D and increased TG/HDL ratio and serum amyloid A compared to healthy controls.
Why the study?
The study was conducted to estimate CIMT, lipid profile, serum amyloid A, and vitamin D in FMF patients and explore the relationship between CIMT and FMF.
Does Familial Mediterranean Fever alter carotid intima-media thickness, lipid profiles, or vitamin D levels in children compared to healthy controls?
Case-Control (n=85)
Does Familial Mediterranean Fever alter carotid intima-media thickness, lipid profiles, or vitamin D levels in children compared to healthy controls?
Children with FMF do not show increased carotid intima-media thickness despite having a higher TG/HDL ratio and lower vitamin D levels, suggesting subclinical atherosclerosis is not yet structurally evident.
No CIMT difference in FMF patients suggests limited subclinical atherosclerosis risk; leaves open vitamin D deficiency's cardiovascular implications.
It was to estimate the carotid intima-media thickness (CIMT), lipid profile, serum amyloid A and vitamin D in Familial Mediterranean Fever (FMF) patients and to explore the relationship between CIMT and FMF. The study comprised forty-five FMF patients diagnosed during the attack free period and 40 healthy children with similar demographic features as control. The diagnosis of the FMF cases was confirmed by clinical, laboratory assessments and confirmed by the molecular diagnosis. The CIMT, lipid profile, complete blood picture, serum amyloid A (SAA) levels, vitamin D and the growth pattern were investigated. The study showed no significant difference of CIMT among patients and controls, significant decrease of vitamin D levels, while lipid profile parameters, triglyceride (TG) to HDL-Cholesterol (HDL-C) ratio, serum amyloid A were significantly increased. A significant correlation was present between the CIMT with the serum cholesterol, low density lipoprotein and triglycerides as well as between SAA and the number of attacks. In addition, vitamin D levels showed significant negative correlation with colchicine. M694I mutation was the most prevalent among FMF patients. Growth parameters were normal in FMF cases. This study sheds light that the normal CIMT in the FMF patients makes it difficult to describe the children as having subclinical atherosclerosis although the higher TG/HDL ratio reflects their risk of atherosclerosis. Moreover, significant decrease of vitamin D in FMF patients was observed. The growth parameters of the FMF patients on regular treatment of colchicine were not affected.
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Mohamed et al. (2020) conducted a case-control in Familial Mediterranean Fever (n=85). Familial Mediterranean Fever vs. Healthy children was evaluated on Carotid intima-media thickness (CIMT), lipid profile, serum amyloid A, and vitamin D levels. Children with Familial Mediterranean Fever had normal carotid intima-media thickness but significantly decreased vitamin D and increased TG/HDL ratio and serum amyloid A compared to healthy controls.
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