Key result
Low prognostic nutritional index is linked to ~380% greater CV death risk in HCM.
Why the study?
The study was conducted to investigate the impact of poor nutritional status assessed by the prognostic nutritional index on the prognosis of patients with hypertrophic cardiomyopathy.
Does a low prognostic nutritional index predict cardiovascular death in patients with hypertrophic cardiomyopathy?
Observational (n=420)
No
Does a low prognostic nutritional index predict cardiovascular death in patients with hypertrophic cardiomyopathy?
Effect estimate: HR 4.8 (95% CI 1.6-14.4)
Absolute Event Rate: 13.6% vs 2.1%
p-value: p=0.005
Poor nutritional status, as assessed by a low prognostic nutritional index, is an independent predictor of cardiovascular death in patients with hypertrophic cardiomyopathy.
May support nutritional risk stratification in hypertrophic cardiomyopathy; hypothesis-generating and should not yet change practice.
Aim: The aim of the study was to investigate poor nutritional status assessed by prognostic nutritional index (PNI) on the prognosis of patients with hypertrophic cardiomyopathy(HCM).Material and Methods: A total of 420 patients with HCM were assessed. The primary end point was defined as the occurrence of CV death that included sudden cardiac death (SCD), death due to HF and cardioembolic stroke-related death. Results: During the follow-up, primary end point was developed in 25 (6.0%) patients. Receiver operating characteristic (ROC) analysis showed that using a cut-off level of 40, PNI predicted the occurrence of primary end point with a sensitivity of 76% and specificity of 76.7%. In the multivariate model, low PNI was significant predictor of the primary end point. Conclusion: This study showed that lowerPNI level is an independent predictor of CV death in patients with HCM.
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Tak et al. (2020) conducted an observational in Hypertrophic cardiomyopathy (n=420). Low prognostic nutritional index (PNI < 40) vs. High prognostic nutritional index (PNI ≥ 40) was evaluated on Cardiovascular death (sudden cardiac death, heart failure death, and cardioembolic stroke-related death) (HR 4.8, 95% CI 1.6-14.4, p=0.005). Low prognostic nutritional index (<40) was an independent predictor of cardiovascular death in patients with hypertrophic cardiomyopathy (HR 4.8).
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