What is the clinical evidence from this study?

Study design: Other. Population: Arrhythmias. Intervention: Pre-ablation measurement of DeltaIMP and DeltaT. Primary outcome: Correlation between the product of DeltaT and DeltaIMP and obtained lesion size (p=<0.001).

What does this research mean for the field?

Pre-ablation measurement of impedance and temperature rise (DeltaIMP and DeltaT) significantly correlates with and can predict the resulting lesion size during radiofrequency ablation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to identify how pre-ablation measurements can predict lesion size after radiofrequency ablation.

September 9, 2005EP EuropaceOpen Access

Indication of the radiofrequency induced lesion size by pre-ablation measurements

Q: What are the key findings of this study?

Pre-ablation measurement of impedance and temperature rise (DeltaIMP and DeltaT) significantly correlated with the obtained lesion size during radiofrequency ablation in vitro (P<0.001).

Q: What does this research mean for the field?

Pre-ablation measurement of impedance and temperature rise (DeltaIMP and DeltaT) significantly correlates with and can predict the resulting lesion size during radiofrequency ablation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

This research aims to identify how pre-ablation measurements can predict lesion size after radiofrequency ablation.

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Key result

Pre-ablation measurement of impedance and temperature rise (DeltaIMP and DeltaT) significantly correlated with the obtained lesion size during radiofrequency ablation in vitro (P<0.001).

Why the study?

Can pre-ablation measurements of impedance and temperature rise indicate the resulting lesion size during radiofrequency ablation?

Population

In vitro strips of left ventricular porcine myocardium

Design

Preclinical

Authors

NSN STAGEGAARDRigshospitalet HPHeidi Huus PetersenDanish Agriculture and Food Council XCXi ChenUniversity of Pittsburgh

Discussion

Member takes

Implication

Should not guide clinical ablation decisions yet; leaves open translation of in vitro lesion prediction to in vivo use.

Key Points

This research aims to identify how pre-ablation measurements can predict lesion size after radiofrequency ablation.
In vitro study performed on porcine myocardium strips.
Measured impedance rise (DeltaIMP) and temperature rise (DeltaT) before ablation.
Conducted radiofrequency ablation under various conditions and determined lesion size.
DeltaIMP significantly increased with improved contact (P < 0.05), unaffected by convective cooling.
DeltaT increased with greater contact pressure (P < 0.05) and decreased with increased cooling (P < 0.001).
Strong correlation found between DeltaT * DeltaIMP and lesion size for both temperature-controlled and power-controlled techniques (P < 0.001).

Structured PICO

Can pre-ablation measurements of impedance and temperature rise indicate the resulting lesion size during radiofrequency ablation?

Population

In vitro strips of left ventricular porcine myocardium

Intervention

Pre-ablation measurement of impedance rise (DeltaIMP) and temperature rise (DeltaT) with a 0.6 W 5 s test pulse, followed by radiofrequency ablation (temperature-controlled, power-controlled, or irrigated tip) using 7F 4 mm tip catheters under varying conditions (cooling, contact pressure, orientation)

Outcome

Correlation between the product of DeltaT and DeltaIMP and the obtained lesion sizesurrogate

Main Result

p-value: p=<0.001

Pre-ablation measurements of impedance and temperature rise can predict lesion size during radiofrequency ablation in an in vitro model.

Cite This Study

STAGEGAARD et al. (2005) studied Arrhythmias. Pre-ablation measurement of DeltaIMP and DeltaT was evaluated on Correlation between the product of DeltaT and DeltaIMP and obtained lesion size (p=<0.001). Pre-ablation measurement of impedance and temperature rise (DeltaIMP and DeltaT) significantly correlated with the obtained lesion size during radiofrequency ablation in vitro (P<0.001).

synapsesocial.com/papers/6a1292e2ea48cb855a351b7d https://doi.org/10.1016/j.eupc.2005.05.016

Topics

AF ablation outcomes

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Indication of the radiofrequency induced lesion size by pre-ablation measurements

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Indication of the radiofrequency induced lesion size by pre-ablation measurements

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider