Continuous positive airway pressure therapy significantly increased the 12-month AF-free survival rate compared to no CPAP (70.3% vs 31.5%; P=0.02) in patients with AF and OSA after ablation.
Cohort (n=182)
Does continuous positive airway pressure (CPAP) therapy reduce the recurrence of atrial fibrillation in patients with obstructive sleep apnea after radiofrequency ablation?
CPAP therapy significantly improves arrhythmia-free survival in patients with atrial fibrillation and obstructive sleep apnea following radiofrequency ablation.
Effect estimate: HR 2.37 (95% CI 1.21-4.96)
Absolute Event Rate: 70.3% vs 31.5%
p-value: p=0.02
This study aimed to determine the effect of continuous positive airway pressure (CPAP) therapy on patients with atrial fibrillation (AF) and obstructive sleep apnea (OSA) after radiofrequency ablation (RFCA).OSA predicts recurrence of AF in patients with AF and OSA after RFCA. However, the effect of CPAP therapy on recurrence of AF in these patients after RFCA is poorly known.All 122 patients who underwent RFCA from 2017 to 2020 were diagnosed OSA by polysomnography. A total of 62 patients were treated by CPAP, while the remaining 60 were not treated by CPAP. The recurrence of atrial tachyarrhythmia and use of antiarrhythmic drugs were compared between the two groups during a follow-up of 12 months. The outcome of these patients with OSA was compared to a group of 60 AF patients undergoing RFCA without OSA.Patients undergoing CPAP therapy had a higher AF-free survival rate compared to non-CPAP-treated patients (70.3% versus 31.5%; P = 0.02). LAD was associated with the risk of AF recurrence in patients with OSA (HR per mm increase: 1.0; 95% CI: 1.06-1.21; P = 0.01). The CPAP nonusers had more than two-fold increased risk of AF recurrence following pulmonary vein isolation (HR: 2.37; 95% CI: 1.21-4.96; P = 0.02).CPAP treatment highly increased arrhythmia-free survival in AF patients accompanied by OSA after RFCA and reduced recurrence of AF in these patients.
Zhou et al. (Wed,) conducted a cohort in Atrial fibrillation and obstructive sleep apnea (n=182). Continuous positive airway pressure (CPAP) vs. No CPAP was evaluated on AF-free survival rate (HR 2.37, 95% CI 1.21-4.96, p=0.02). Continuous positive airway pressure therapy significantly increased the 12-month AF-free survival rate compared to no CPAP (70.3% vs 31.5%; P=0.02) in patients with AF and OSA after ablation.