Key result
CPAP linked to ~137% greater 12-month AF-free survival after ablation in patients with OSA.
Why the study?
OSA predicts AF recurrence after RFCA, but the effect of CPAP therapy on AF recurrence in these patients after RFCA is poorly known.
Does continuous positive airway pressure (CPAP) therapy reduce the recurrence of atrial fibrillation in patients with obstructive sleep apnea after radiofrequency ablation?
Population
122 patients with AF and OSA undergoing RFCA and 60 AF patients without OSA
Comparison
CPAP therapy vs no CPAP therapy (and vs patients without OSA)
Design
Cohort study
Follow-up
12 months
Authors
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May support CPAP to improve AF-free survival after ablation in OSA; hypothesis-generating pending randomized confirmation.
Cohort (n=182)
Does continuous positive airway pressure (CPAP) therapy reduce the recurrence of atrial fibrillation in patients with obstructive sleep apnea after radiofrequency ablation?
Effect estimate: HR 2.37 (95% CI 1.21-4.96)
Absolute Event Rate: 70.3% vs 31.5%
p-value: p=0.02
CPAP therapy significantly improves arrhythmia-free survival in patients with atrial fibrillation and obstructive sleep apnea following radiofrequency ablation.
Zhou et al. (2022) conducted a cohort in Atrial fibrillation and obstructive sleep apnea (n=182). Continuous positive airway pressure (CPAP) vs. No CPAP was evaluated on AF-free survival rate (HR 2.37, 95% CI 1.21-4.96, p=0.02). Continuous positive airway pressure therapy significantly increased the 12-month AF-free survival rate compared to no CPAP (70.3% vs 31.5%; P=0.02) in patients with AF and OSA after ablation.
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