Key result
Review outlines a theoretical framework for natural product-based therapies targeting mitochondria-endoplasmic reticulum coupling in HF.
Why the study?
This review aimed to address current limitations in natural compounds research and clinical translation, providing a theoretical framework for therapies targeting the MERC-HF axis.
This review outlines a theoretical framework for using natural compounds to target mitochondria-endoplasmic reticulum structural coupling in heart failure.
flux, alleviating lipotoxicity, and exerting synergistic antioxidant effects. Furthermore, we critically discuss the current limitations of natural compounds research, including the challenges in establishing definitive structure-activity relationships, and address the major challenges in clinical translation and therapeutic delivery. By integrating mechanistic insights with pharmacological intervention, this review aims to provide a comprehensive theoretical framework for the development of precise, natural product-based therapies targeting the MERC-HF axis.
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Zhang et al. (2026) conducted a review in Heart Failure. Natural product-based therapies was evaluated. This review outlines a theoretical framework for developing precise, natural product-based therapies targeting mitochondria-endoplasmic reticulum structural coupling in heart failure.
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