Key result
NAG was significantly elevated in acute coronary syndrome compared with chest wall syndrome and controls, and served as an independent predictor for the diagnosis of myocardial infarction.
Why the study?
The study evaluated the role of the tubular biomarkers NAG, KIM-1, and NGAL in patients presenting with chest pain before contrast media exposition.
Do tubular biomarkers (NAG, KIM-1, NGAL) correlate with cardiac impairment and predict myocardial infarction in patients presenting with chest pain?
Observational (n=270)
Do tubular biomarkers (NAG, KIM-1, NGAL) correlate with cardiac impairment and predict myocardial infarction in patients presenting with chest pain?
Answers are grounded in this paper and cite their sources.
NAG may serve as an early marker of acute cardiorenal syndrome and an independent predictor of myocardial infarction in patients presenting with chest pain.
Aim: We evaluated the role of the tubular biomarkers N-acetyl-ß-D-glucosaminidase (NAG), kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with chest pain. Methods: Serum and urine samples were collected of 223 patients and 47 healthy controls. None of them was exposed to contrast media. Results: NAG showed among others significant correlation with N-terminal pro brain natriuretic peptide (NTproBNP), troponin I and creatinine. KIM-1 and NGAL showed weaker correlations. NAG was significantly elevated in all subgroups of acute coronary syndrome (ACS) compared with chest wall syndrome and controls. NAG was an independent predictor for the diagnosis of myocardial infarction. Conclusion: NAG may demonstrate the presence of acute tubular injury due to cardiac impairment already in the emergency department. NAG should be evaluated as marker of acute cardiorenal syndrome in patients with chest pain.
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Schlossbauer et al. (2019) conducted an observational in Chest pain (n=270). Tubular biomarkers (NAG, KIM-1, NGAL) vs. Healthy controls and chest wall syndrome was evaluated on Correlation with cardiac markers and prediction of myocardial infarction. NAG was significantly elevated in acute coronary syndrome compared with chest wall syndrome and controls, and served as an independent predictor for the diagnosis of myocardial infarction.
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