Why the study?
Post-infectious bronchiolitis obliterans leads to persistent inflammation and fibrotic changes in small airways, but its underlying molecular mechanisms remain to be clarified.
Does transcriptome profiling of induced sputum identify differentially expressed genes and altered signaling pathways in patients with post-infectious bronchiolitis obliterans compared to healthy controls?
Population
Nine patients with PiBO and eight healthy controls
Comparison
PiBO patients vs healthy controls
Design
Case-control study
Key result
Transcriptome analysis of sputum cells from PiBO patients revealed significant upregulation of TNFα-dependent NFκB signalling and downregulation of oxidative phosphorylation versus healthy controls.
Authors
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May highlight TNFα/NF-κB targets for PiBO therapy; leaves open clinical utility pending prospective trials.
Case-Control (n=17)
Does transcriptome profiling of induced sputum identify differentially expressed genes and altered signaling pathways in patients with post-infectious bronchiolitis obliterans compared to healthy controls?
Transcriptome profiling of sputum cells in PiBO patients reveals a shift in macrophage polarization, upregulated TNF-α/NF-κB signaling, and downregulated mitochondrial function, which correlate with lung function decline.
Jerkic et al. (2026) conducted a case-control in Post-infectious bronchiolitis obliterans (PiBO) (n=17). Transcriptome profiling of induced sputum vs. Healthy controls was evaluated on Differentially expressed genes (DEGs) in sputum cells. Transcriptome analysis of sputum cells from PiBO patients revealed significant upregulation of TNFα-dependent NFκB signalling and downregulation of oxidative phosphorylation versus healthy controls.
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