Key result
High-normal blood pressure linked to ~11% lower LV global radial strain versus healthy controls.
Why the study?
The study sought to evaluate changes in LV strain and native T1/T2 mapping characteristics on CMR in patients with high-normal blood pressure.
Does high-normal blood pressure lead to impaired left ventricular strain and native T1/T2 mapping characteristics on CMR compared to healthy controls?
Case-Control (n=50)
No
Does high-normal blood pressure lead to impaired left ventricular strain and native T1/T2 mapping characteristics on CMR compared to healthy controls?
High-normal blood pressure is associated with subclinical impairment of left ventricular mechanics detectable by CMR strain imaging, even in the absence of interstitial fibrosis.
Answers are grounded in this paper and cite their sources.
High-normal BP was associated with impaired LV strain on CMR; leaves open whether strain imaging aids early risk stratification.
Introduction: The study sought to evaluate changes in left ventricular (LV) strain and native T1/T2 mapping characteristics on cardiac magnetic resonance imaging (CMR) in patients with high-normal blood pressure (HNBP). Methods: A prospective case-control study including 25 cases having HNBP and 25 age- and sex-matched healthy controls was conducted. LV strain was evaluated on CMR using feature tracking and 2-dimensional and 3-dimensional longitudinal, circumferential and radial strain values were calculated. Native T1/T2 mapping values were also calculated. Results: Subclinical impairment of LV mechanics was evident in the form of deranged LV strain parameters in cases with HNBP compared to controls. The two-dimensional global radial (25.34±3.06 vs. 28.52±5.69; P=0.0323), global circumferential (-16.05±1.31 vs. -17.27±2.23; P=0.0241) and global longitudinal strain (-16.33±2.24 vs. -16.49±7.25); P=0.0193) and three-dimensional global circumferential strain (-13.94±10.81 vs. -17.84±2.78; P=0.0133) values were significantly impaired in cases compared to controls. No significant difference was observed in the native T1/T2 mapping parameters. Conclusion: LV strain parameters are significantly deranged in patients with HNBP, compared to healthy controls, in the absence of other morphological changes or interstitial fibrosis. Impaired LV strain parameters can serve as a new marker for detection of subclinical myocardial dysfunction in patients with HNBP having preserved chamber function.
No takes yet. Share an insight, caveat, or question.
Khurana et al. (2026) conducted a case-control in High normal blood pressure (n=50). High normal blood pressure vs. Healthy controls (SBP < 120 and DBP < 80 mm Hg) was evaluated on 2D global radial strain (p=0.0323). Patients with high normal blood pressure exhibited significantly impaired left ventricular mechanics, including reduced two-dimensional global radial strain (25.34% vs 28.52%), compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: