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May 24, 2026ToxicsOpen Access

Chlorination of Clothianidin During Disinfection: Kinetics, Pathways, and Toxicity

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Authors

FWFang WeiLWLei WuFMFei Meng

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Overview

Randomized trial investigates chlorination's effects on cytotoxicity in neonicotinoid pesticides, indicating important water safety implications.

Key Points

  • This study aims to investigate the chlorination kinetics and transformation pathways of clothianidin and evaluate its cytotoxicity changes after chlorination.
  • Measured chlorination kinetics of clothianidin using second-order reactions at pH 7.0.
  • Assessed the cytotoxicity in Chinese Hamster Ovary (CHO) cell assays.
  • Evaluated the effects of pH and dissolved organic matter on chlorination rates.
  • Chlorination of clothianidin showed a rate constant (kapp) of 1.758 × 10−4 μM−1 h−1 at pH 7.0.
  • Cytotoxicity of clothianidin decreased significantly post-chlorination, indicating reduced harmful effects.
  • Chlorination yields disinfection byproducts like trihalomethanes and haloacetic acids, which follow similar kinetics.

Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/6a1296b248a0ea1665673b75https://doi.org/10.3390/toxics14060453
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