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May 24, 2026F1000ResearchOpen Access

Predictive value of miR-122-5p, miR-449a, miR-30b-5p, miR-34c-5p, miR-34b-5p in sperm recovery from testicular tissue of azoospermic infertile men

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Authors

EMElahe MojiSMSeyed Mohsen MiresmaeiliMIMaryam Imani

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Overview

Randomized trial demonstrates the predictive value of specific microRNAs for sperm retrieval in azoospermic men, suggesting their utility as biomarkers.

Key Points

  • The study aims to evaluate specific microRNAs as predictors for sperm recovery from testicular tissue in azoospermic men.
  • Azoospermic male patients were recruited and categorized into obstructive and non-obstructive groups.
  • Testicular tissue was obtained through microdissection testicular sperm extraction.
  • MicroRNA expression levels were measured using qRT-PCR, with statistical analysis conducted using SPSS.
  • miR-34b-5p, miR-449a, and miR-30b-5p were significantly lower in azoospermic patients versus controls, indicating a role in spermatogenesis.
  • miR-34c-5p showed slight upregulation, potentially suggesting a compensatory role in sperm maturation.
  • miR-122-5p expression was relatively unchanged, indicating limited predictive value.

Cite This Study

Moji et al. (2026) studied this question.

synapsesocial.com/papers/6a1296c748a0ea1665673d78https://doi.org/10.12688/f1000research.178266.1
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Also Consider

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  1. 1Serum miRNAs as Potential Diagnostic Biomarkers for Non-Obstructive Azoospermia2024
  2. 2Expression of exosomal microRNAs miR-34a and miR-210 in male infertility: relationship with morphokinetic parameters and sperm DNA fragmentation2024 · 2 citations
  3. 3MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers2024 · 53 citations
  4. 4Identification of biomarkers for non-obstructive azoospermia based on microRNA and bioinformatics screening.2026
  5. 5(183) The Predictive Value of AMH, FSH, and Inhibin B for Sperm Retrieval in Azoospermic Men2024