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May 24, 2026Case Reports in DentistryOpen Access

First Reported Coexistence of Plasma Cell Gingivitis and Multiple Sclerosis: A Case Report

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Authors

HTHamid TaherniaBBBahareh Todeshki BagheriMSMohammad Shahdadian

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Overview

Case report highlights the rare coexistence of plasma cell gingivitis and MS, suggesting potential shared mechanisms.

Key Points

  • This case report aims to present the unique coexistence of plasma cell gingivitis and multiple sclerosis, a previously undocumented association.
  • Clinical examination of a 26-year-old woman with MS presenting gingival issues.
  • Histopathological analysis confirming diagnosis of plasma cell gingivitis via incisional biopsy.
  • Patient treated with corticosteroid mouthwash, followed over a period of 6 months for improvement and monitoring.
  • Significant improvement in gingival erythema after treatment with corticosteroid mouthwash.
  • No exacerbation of multiple sclerosis symptoms noted during the follow-up period.
  • The coexistence of PCG and MS raises questions about possible shared immunologic pathways.

Cite This Study

Tahernia et al. (2026) studied this question.

synapsesocial.com/papers/6a1296d548a0ea1665673e06https://doi.org/10.1155/crid/2629260
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Cell Gingivitis: Clinical Presentation, Histopathologic Correlation, and Therapeutic Challenges2025
  2. 2Challenges and solutions in plasma cell gingivitis: A clinical case analysis2024
  3. 3Plasma Cell Gingivitis: A Clinicopathological Case Report Highlighting a Systematic Diagnostic Approach and Step-by-Step Surgical Management2026
  4. 4Gingival Plasma Cell Granuloma Mimicking Malignancy in a Pediatric Patient with Poor Oral Hygiene and Malnutrition: A Case Report2026
  5. 5Plasma Cell Mucositis: A Differential Diagnosis–Oriented Case Report2026