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May 1, 2026HLA

Identification of the Novel HLA‐C*12:449 Allele During Routine Pre‐Transplant HLA Typing

Hiteshree Buch Akshay Chaudhary Mahin Muhammed Sandip Shah Prabin Kumar

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Key Points

The aim is to identify the novel HLA-C*12:449 allele and understand its genetic characteristics.
Routine pre-transplant HLA typing was performed to identify HLA alleles.
Comparison of HLA-C*12:449 with HLA-C*12:02:02:01 was conducted to determine differences.
HLA-C*12:449 was successfully identified during typing.
The allele differs from HLA-C*12:02:02:01 by a single non-synonymous change in exon 7.

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Implication

Novel allele identification reveals genetic variations in HLA types, suggesting implications for transplant compatibility.

Abstract

HLA-C*12:449 differs from HLA-C*12:02:02:01 by a single non-synonymous change in exon 7.

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Cite This Study

Buch et al. (2026) studied this question.

synapsesocial.com/papers/6a1296d548a0ea1665673f9e https://doi.org/10.1111/tan.70766

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