Key result
Early focal hypodensity on CT within 5 hours of stroke onset predicted subsequent hemorrhagic transformation in 77% of cases (95% CI, 68-86%), independent of anticoagulation.
Observational (n=150)
Absolute Event Rate: 77% vs 6%
Early focal hypodensity on CT within 5 hours of stroke onset reliably predicts subsequent hemorrhagic transformation, which itself does not independently worsen prognosis apart from massive hematomas.
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May support early CT risk stratification in acute stroke; hypothesis-generating and requires prospective validation before practice change.
Toni et al. (1996) conducted an observational in Cerebral anterior circulation infarct (n=150). Early focal hypodensity on CT vs. Absence of early focal hypodensity was evaluated on Hemorrhagic transformation (HT) within the first week. Early focal hypodensity on CT within 5 hours of stroke onset predicted subsequent hemorrhagic transformation in 77% of cases (95% CI, 68-86%), independent of anticoagulation.
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