Association between asymmetric dimethylarginine serum levels and left ventricular longitudinal deformation in patients with normal ejection fractions: a two-dimensional speckle-tracking echocardiography examination

OBJECTIVES: Nitric oxide is an endogenous substance that preserves the myocardial function in patients with heart failure. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of endogenous nitric oxide synthase. We sought to explore the association between the left ventricular (LV) function as assessed with two-dimensional echocardiography and the serum level of ADMA in nondiabetic patients without significant coronary artery disease. PATIENTS AND METHODS: Eighty-seven consecutive patients with normal LV ejection fractions were included in this cross-sectional study. The ADMA serum level was measured, and the longitudinal deformation indices of the LV myocardium were evaluated using two-dimensional speckle-tracking echocardiography (2DSTE). RESULTS: The systolic strain, the systolic strain rate, and the early and late diastolic strain rates as evaluated with 2DSTE were not statistically significantly different between the patients with normal ADMA serum levels and those with increased ADMA serum levels. The two study groups were also not significantly different in terms of the systolic and diastolic myocardial velocities obtained with tissue Doppler. CONCLUSION: Our findings showed no statistically significant correlations between the serum ADMA level and the 2DSTE-derived indices of the longitudinal deformation of the LV myocardium in our nondiabetic patients without significant coronary artery stenosis and with normal LV ejection fractions.