Key result
ADMA concentrations in the highest tertile increased the risk of cardiac decompensation, MACE, or mortality compared to the lowest tertile (HR 2.00; 95% CI 1.01-3.97; P=0.046).
Why the study?
Are elevated asymmetrical dimethylarginine (ADMA) concentrations associated with increased cardiovascular risk in patients with symptomatic chronic heart failure?
Population
253 patients with symptomatic chronic heart failure and impaired left ventricular function, median age 70…
Comparison
Highest tertile of asymmetrical dimethylarginine… vs Lowest tertile of asymmetrical dimethylarginine…
Design
Cohort
Follow-up
median 14.2 months
Authors
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Elevated ADMA plasma concentrations, particularly when combined with NT-proBNP, significantly improve risk stratification for adverse cardiovascular outcomes in patients with chronic heart failure.
Cohort (n=253)
Are elevated asymmetrical dimethylarginine (ADMA) concentrations associated with increased cardiovascular risk in patients with symptomatic chronic heart failure?
Effect estimate: HR 2.00 (95% CI 1.01 to 3.97)
p-value: p=0.046
Elevated ADMA plasma concentrations, particularly when combined with NT-proBNP, significantly improve risk stratification for adverse cardiovascular outcomes in patients with chronic heart failure.
Dückelmann et al. (2007) conducted a cohort in chronic heart failure (n=253). Highest tertile of ADMA concentrations vs. Lowest tertile of ADMA concentrations was evaluated on cardiac decompensation, major adverse cardiovascular events or all-cause mortality (HR 2.00, 95% CI 1.01 to 3.97, p=0.046). ADMA concentrations in the highest tertile increased the risk of cardiac decompensation, MACE, or mortality compared to the lowest tertile (HR 2.00; 95% CI 1.01-3.97; P=0.046).
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