Key result
Forearm clearance of [(3)H]L-arginine was significantly reduced in patients with congestive heart failure compared to control subjects (64 vs 133 mL/min, P=0.002).
Why the study?
Does congestive heart failure impair L-arginine transport compared to control subjects?
Observational
Does congestive heart failure impair L-arginine transport compared to control subjects?
Absolute Event Rate: 64% vs 133%
p-value: p=0.002
L-arginine transport is markedly depressed in human congestive heart failure, providing a mechanistic explanation for endothelial dysfunction and the potential benefit of supplemental L-arginine.
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Impaired L-arginine transport may contribute to endothelial dysfunction in heart failure; leaves open whether supplementation improves outcomes.
Kaye et al. (2000) conducted an observational in Congestive heart failure (CHF). [(3)H]L-arginine vs. Control subjects was evaluated on Forearm clearance of [(3)H]L-arginine (p=0.002). Forearm clearance of [(3)H]L-arginine was significantly reduced in patients with congestive heart failure compared to control subjects (64 vs 133 mL/min, P=0.002).
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