Key result
Diabetic patients with symptomatic heart failure had a significantly lower ejection fraction compared to non-diabetic patients (43.24% vs. 47.15%, P=0.002).
Why the study?
The study was conducted to evaluate the role of NT-proBNP levels in determining the severity of heart failure in diabetic patients.
What are the echocardiographic and lipid profile differences in diabetic versus non-diabetic patients presenting with symptomatic heart failure?
Observational (n=150)
No
What are the echocardiographic and lipid profile differences in diabetic versus non-diabetic patients presenting with symptomatic heart failure?
Diabetic patients with symptomatic heart failure exhibit worse left ventricular systolic function and a more atherogenic lipid profile compared to other heart failure patients.
Answers are grounded in this paper and cite their sources.
May warrant closer EF monitoring in diabetic HF; leaves open diabetes-specific mechanisms or interventions.
BACKGROUND: Diabetic patients are at higher risk of cardiovascular morbidity and mortality. NT-proBNP levels measurements are useful for the assessment of risk in heart failure patients in emergency condition and give the faster result. Further, it also offers lower cost and unnecessary hospitalization and follow-up cost. The studies have shown that NT-proBNP levels are a direct predictor of outcome risk in diabetic patients with heart failure. The objective of this research was to study the role of NT-proBNP levels to determine the severity of heart failure in diabetic patients. MATERIALS AND METHODS: In this study 150 patients diagnosed with symptomatic heart failure admitted to the emergency department of a tertiary care center from January 2021 to January 2022 have been included in Saraswati Institute Of Medical Sciences, Hapur, India. N-terminal pro-B-type natriuretic peptide (NT-Pro-BNP) levels were measured using an automated analyzer ranging between 60 and 3000 pg/ml. According to the European society of cardiology (ESC) guidelines, it has been defined as NT-Pro-BNP level above 125 pg/ml indicates a high possibility of heart failure and NT-Pro-BNP level below 125 pg/ml excludes the high possibility of heart failure. All the patients underwent an echocardiographic study and ejection fraction was calculated and recorded. RESULTS: In diabetic patients ejection fraction was significantly lower in diabetic patients: 47.15 ± 8.75% vs. 43.24 ± 9.54%, P = 0.002). We have observed statistically significant lower HDL values (40.10 ± vs. 35.94 mg/dL, P = 0.0004), however, significant higher triglycerides values were found (101.43 ± 41.7 mg/dL vs. 151.37 ± 78.85, P = 0.001). No significant difference was observed in LDL level (97.8 ± 31.23 vs. 92.35 ± 314.2, P ≥ 0.05) and total cholesterol level (161.49 ± 41.38 vs. 159.97 ± 41.12, P ≥ 0.05). CONCLUSION: We concluded that the measurement of NT-proBNP in heart failure and diabetic patients could be an economic marker for the evaluation of morbidity and mortality, facilitating better management and follow-up.
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Siddiqui et al. (2024) conducted an observational in Symptomatic heart failure (n=150). Diabetes vs. Non-diabetic was evaluated on Ejection fraction (p=0.002). Diabetic patients with symptomatic heart failure had a significantly lower ejection fraction compared to non-diabetic patients (43.24% vs. 47.15%, P=0.002).
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