Key result
Hypertension links to central aortic stiffness, while concurrent T2D associates with greater peripheral vascular stiffness.
Why the study?
The study was conducted to compare vascular stiffness and the presence of traditional cardiovascular risk factors in middle-aged men with arterial hypertension and type 2 diabetes mellitus.
How does the presence of type 2 diabetes mellitus affect central and peripheral vascular stiffness in middle-aged men with hypertension?
Cross-Sectional (n=180)
How does the presence of type 2 diabetes mellitus affect central and peripheral vascular stiffness in middle-aged men with hypertension?
The coexistence of type 2 diabetes and hypertension in middle-aged men exacerbates peripheral vascular stiffness, whereas hypertension alone is associated with more severe central arterial stiffness.
May inform differential vascular phenotyping in hypertensive men with diabetes; leaves open causal links and outcome prediction.
Objective . Comparison of vascular stiffness and a presence of traditional risk factors of cardiovascular diseases (CVD) in middle-aged men with arterial hypertension (HTN) and type 2 diabetes mellitus (DM). Design and methods . We examined 180 middle-aged men. All patients were divided into 3 groups of 60 people: group 1 (control) — healthy normotensive patients, group 2 (HTN) — patients with hypertension and group 3 (HTN and DM) — with hypertension and diabetes. All subjects underwent 24hours ABPM with assessment of routine and average daily parameters of blood pressure (BP), indicators of central and peripheral vascular stiffness. Results . The average daily values of systolic blood pressure (SBP) and pulse blood pressure (PBP) differ significantly between all pairs of groups, with the highest PBP in group 2. Subjects in groups 2 (HTN) and 3 (HTN + DM) had significantly higher average diastolic blood pressure (DBP). The average indicators of BP variability are worse in group 3 (HTN + DM), both for DBP and SBP. The following differences in central parameters of vascular stiffness and central pressure in the aorta were identified: DBP in the aorta (DBP ao) and mean blood pressure in the aorta (MAP ao) are higher in group 2. The augmentation index in the aorta (Alx ao) is higher in group 3, PAD amplification (PPA) and reflected wave propagation time (RWTT) are higher in group 2. Conclusions . In middle-aged men with HTN central SBP and PBP, aortic and peripheral stiffness are greater than in the control group. Central stiffness is more severe in HTN patients. Peripheral indicators of vascular stiffness are more increased in patients with HTN and DM.
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Gomonova et al. (2025) conducted a cross-sectional in Arterial hypertension and type 2 diabetes mellitus (n=180). Arterial hypertension with or without type 2 diabetes mellitus vs. Healthy normotensive controls was evaluated on Central and peripheral vascular stiffness and 24-hour blood pressure parameters. Middle-aged men with hypertension had greater central aortic stiffness than controls, while peripheral vascular stiffness was more increased in patients with both hypertension and type 2 diabetes.
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