Key result
Older age is linked to a diminished pressure-natriuresis response compared to younger individuals.
Why the study?
Age-related alterations in renal sodium handling affect blood pressure, prompting the study to clarify whether the pressure-natriuresis response changes with age, leading to blood pressure elevation.
Does the pressure-natriuresis response change with age in individuals with normal renal function or non-diabetic chronic kidney disease?
Observational (n=5,094)
Yes
Does the pressure-natriuresis response change with age in individuals with normal renal function or non-diabetic chronic kidney disease?
Answers are grounded in this paper and cite their sources.
The pressure-natriuresis response is diminished in older individuals regardless of chronic kidney disease status, which may alter how blood pressure responds to sodium intake and antihypertensive therapy.
BACKGROUND: Age-related alterations in renal sodium handling affect blood pressure (BP). We aimed to clarify whether the pressure-natriuresis response changes with age, leading to BP elevation. METHODS: A total of 4,859 participants with normal renal function from the Korean Genome and Epidemiology Study (KoGES) and 235 patients with non-diabetic chronic kidney disease (CKD) from the ESPECIAL trial were included and divided into the younger and older groups. In ESPECIAL, participants took olmesartan from weeks 0 to 16 and were educated about a low-salt diet (LSD) from weeks 8 to 16. RESULTS: In both studies, older participants showed lower estimated glomerular filtration rate (eGFR) and urine concentration index and higher albuminuria. In KoGES, BP was higher and urine sodium was lower in older participants. In ESPECIAL, diastolic BP at 0 week was lower in older participants. Olmesartan reduced BP in both groups, whereas LSD decreased systolic BP only in older participants. Urine sodium increased in younger participants but decreased in older participants after olmesartan use. In KoGES, urine sodium was correlated with BP in both groups after adjusting for age, sex, and eGFR; however, the correlation coefficient was lower in older participants. In ESPECIAL, only younger participants showed a significant positive association between systolic BP and urine sodium in multiple regression analysis. CONCLUSIONS: The pressure-natriuresis response was diminished in older participants with or without CKD.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2022) conducted an observational in Normal renal function and non-diabetic chronic kidney disease (n=5,094). Older age vs. Younger age was evaluated on Correlation between blood pressure and urine sodium excretion (pressure-natriuresis response). Older age was associated with a diminished pressure-natriuresis response, demonstrating a weaker or absent correlation between blood pressure and urine sodium excretion compared to younger individuals.
Synapse has enriched 10 related papers. Consider them for comparative context: