Why the study?
Does varying salt intake affect mean arterial blood pressure in subjects with essential hypertension, and what factors determine this response?
Population
46 white, nonobese subjects with essential hypertension
Comparison
1 week of high salt intake (300 mmol sodium/day) vs 1 week of low salt intake (20 mmol sodium/day)
Design
RCT, randomized, double-blind
Follow-up
1 week per diet phase
Authors
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May warrant prioritizing salt restriction in older essential hypertensives; confirms age as key determinant of salt sensitivity.
Does varying salt intake affect mean arterial blood pressure in subjects with essential hypertension, and what factors determine this response?
Age is a major determinant of salt sensitivity in essential hypertension, with older patients exhibiting greater blood pressure increases in response to high salt intake.
Overlack et al. (1995) studied this question.
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