What question did this study set out to answer?

To prospectively investigate the association between serum uric acid concentrations and risks of all-cause mortality, cardiovascular disease mortality, and myocardial infarction.

July 1, 1999Epidemiology

Prenatal Methylmercury Exposure as a Cardiovascular Risk Factor at Seven Years of Age

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Authors

NSNicolina SørensenUniversity of the Faroe Islands KMKatsuyuki MurataAkita University EBEsben Budtz–JørgensenUniversity of Copenhagen

Discussion

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Implication

Prospective cohort study demonstrates increased all-cause and cardiovascular mortality with high uric acid in men, suggesting an independent metabolic risk marker.

Key Points

To prospectively investigate the association between serum uric acid concentrations and risks of all-cause mortality, cardiovascular disease mortality, and myocardial infarction.
Followed 1,044 men aged 45–64 years from the WHO MONICA Augsburg cohort from 1984–1985 through 1992.
Estimated hazard rate ratios (HRR) using Cox proportional hazards models adjusted for alcohol intake, total-to-HDL cholesterol ratio, hypertension, diuretic use, smoking, BMI, and education.
Serum uric acid ≥373 µmol/L versus ≤319 µmol/L independently predicted all-cause mortality (HRR = 2.8; 95% CI = 1.6–5.0) after multivariable adjustment.
Adjusted risk for cardiovascular disease mortality was elevated at HRR = 2.2 (95% CI = 1.0–4.8) across the 44 recorded cardiovascular deaths.
Adjusted risk for fatal or nonfatal myocardial infarction was HRR = 1.7 (95% CI = 0.8–3.3) across 60 incident cases.

Cite This Study

Sørensen et al. (1999) studied this question.

synapsesocial.com/papers/6a12ac2b375951284434c66e https://doi.org/10.1097/00001648-199907000-00006

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Implication

Prospective cohort study demonstrates increased all-cause and cardiovascular mortality with high uric acid in men, suggesting an independent metabolic risk marker.

Prenatal Methylmercury Exposure as a Cardiovascular Risk Factor at Seven Years of Age

Discussion

Member takes

Implication

Key Points

Cite This Study

Prenatal Methylmercury Exposure as a Cardiovascular Risk Factor at Seven Years of Age

Discussion

Member takes

Implication

Key Points

Cite This Study

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Also Consider