Uric Acid Levels Are Associated With All-Cause and Cardiovascular Disease Mortality Independent of Systemic Inflammation in Men From the General Population
Key result
High serum uric acid levels were independently associated with increased cardiovascular disease mortality (HR 1.44; 95% CI 1.04-2.0) and all-cause mortality in middle-aged men.
Why the study?
Are high serum uric acid levels associated with increased cardiovascular disease mortality, all-cause mortality, and incident myocardial infarction in middle-aged men from the general population?
Population
3,604 men aged 45 to 74 years from the general population who participated in the MONICA Augsburg surveys
Comparison
High serum uric acid levels vs Low serum uric acid (UA) levels (lowest quartile)
Design
Cohort
Follow-up
Up to December 31, 2002 (enrolled between 1984 and 1995)
Authors
Discussion
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Member takes
Implication
High uric acid may identify higher-risk middle-aged men; leaves open causality and whether lowering levels improves outcomes.
Study Design
Type
Cohort (n=3,604)
Structured PICO
Are high serum uric acid levels associated with increased cardiovascular disease mortality, all-cause mortality, and incident myocardial infarction in middle-aged men from the general population?
P
Population
3,604 men aged 45 to 74 years from the general population, prospectively followed up to December 2002 to assess the association of uric acid with mortality.
E
Exposure
High serum uric acid (UA) levels (highest quartile)
C
Comparator
Low serum uric acid (UA) levels (lowest quartile)
O
Outcome
Cardiovascular disease (CVD) mortality, all-cause mortality, and incident (fatal and nonfatal) myocardial infarction (MI)hard clinical
Main Result
Hazard Ratio: 1.44 (95% CI 1.04–2)
High serum uric acid levels are independently associated with increased risk of cardiovascular and all-cause mortality, but not incident MI, in middle-aged men from the general population.
Cite This Study
Meisinger et al. (2008) conducted a cohort in General population (n=3,604). High serum uric acid (UA) levels vs. Low serum uric acid levels (lowest quartile) was evaluated on Cardiovascular disease (CVD) mortality (HR 1.44, 95% CI 1.04-2.0). High serum uric acid levels were independently associated with increased cardiovascular disease mortality (HR 1.44; 95% CI 1.04-2.0) and all-cause mortality in middle-aged men.