Key result
A 37-year-old man with influenza A and sickle cell trait developed severe rhabdomyolysis with a creatine kinase level over 1 million IU/L, requiring continuous veno-venous haemodiafiltration.
Case Report (n=1)
Highlights a rare presentation of extreme rhabdomyolysis and acute kidney injury in a patient with concurrent influenza A infection and sickle cell trait.
Extreme rhabdomyolysis may occur with influenza A and sickle cell trait; case report leaves open causality and screening implications.
Summary We describe the case of a 37‐year‐old normally fit and well man who presented to hospital with fever, lethargy and myalgia. He was found to have a creatine kinase level of over 1 million IU.l −1 . He initially underwent fluid resuscitation, but despite this his renal function declined and he required continuous veno‐venous haemodiafiltration. Subsequent testing revealed a positive viral swab for influenza A and that he was a carrier of sickle cell trait. We review the literature for previous reports describing this association and demonstrate the rarity of such a presentation.
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Bamber et al. (2019) conducted a case report in Elevated creatine kinase (rhabdomyolysis), influenza A infection, sickle cell trait (n=1). Fluid resuscitation and continuous veno-venous haemodiafiltration was evaluated. A 37-year-old man with influenza A and sickle cell trait developed severe rhabdomyolysis with a creatine kinase level over 1 million IU/L, requiring continuous veno-venous haemodiafiltration.
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