Why the study?
Does high-dose oseltamivir and intravenous fluids improve severe rhabdomyolysis and acute renal failure due to influenza A infection?
Does high-dose oseltamivir and intravenous fluids improve severe rhabdomyolysis and acute renal failure due to influenza A infection?
Highlights influenza A as a potential etiology for severe rhabdomyolysis and acute renal failure, which may respond to high-dose oseltamivir and intravenous fluids.
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High-dose oseltamivir may aid influenza rhabdomyolysis recovery; leaves open confirmation in prospective studies.
Rhabdomyolysis is characterised by muscle breakdown with release of damaging proteins that can have devastating consequences. Acute influenza infection is being increasingly recognised as an underlying aetiology. We report an unusual case of severe rhabdomyolysis with acute renal failure due to influenza A infection that improved with high-dose oseltamivir and intravenous fluids. In our case, we also noticed a temporal relation between fever spikes and subsequent increase in serum creatine kinase. The precise mechanism between the rise in temperature and creatine kinase is unclear but it could be due to direct viral invasion of myocytes or due to release of new viral progeny following replication in the myocyte.
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Runnstrom et al. (2018) studied this question.
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