Key result
Acute coronary syndrome was associated with a significant increase in neutrophil lactate content and active oxygen radical formation compared to controls.
Observational (n=96)
No
Acute coronary syndrome is associated with increased oxidative stress and lactate accumulation in neutrophils due to insufficient antioxidative compensation.
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Neutrophil lactate rise may signal oxidative stress in ACS; hypothesis-generating for biomarkers or targets, pending prospective studies.
The contents of lactate and intracellular oxygen metabolism at neutrophils in 56 patients with acute coronary syndrome have been investigated. In the process of weighting acute coronary syndrome, the growth of formation of active oxygen radicals at neutrophils (growth of parameters the test of nitroblue tetrazolium reduction and myeloperoxidase activity) which was not compensated by sufficient increase in intracellular activity of enzymes of antioxidative system protection (catalase activity), and was accompanied by accumulation the lactate in neutrophils.
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Andrey Kratnov (2015) conducted an observational in Acute Coronary Syndrome (n=96). Acute Coronary Syndrome (Exposure) vs. Patients without coronary heart disease was evaluated on Neutrophil lactate content (mMol/l) (p=0.002). Acute coronary syndrome was associated with a significant increase in neutrophil lactate content and active oxygen radical formation compared to controls.
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