Higher baseline heart rate and lower pulse wave velocity predicted significant 24-hour systolic BP reduction after renal denervation (WMD -4.05 and -7.20, respectively).
Meta-Analysis
Do patient-specific factors predict blood pressure reduction after renal denervation in patients with hypertension?
Higher baseline heart rate and lower pulse wave velocity predict a more significant blood pressure reduction following renal denervation in hypertensive patients.
Estimación del efecto: WMD -4.05 (higher HR); WMD -7.20 (lower PWV) (95% CI -7.33 to -0.77 (higher HR); -9.79 to -4.62 (lower PWV))
BACKGROUND: The accurate selection of patients likely to respond to renal denervation (RDN) is crucial for optimizing treatment outcomes in patients with hypertension. This systematic review was designed to evaluate patient-specific factors predicting the RDN response. METHODS AND RESULTS: We focused on individuals with hypertension who underwent RDN. Patients were categorized based on their baseline characteristics. The primary outcome was blood pressure (BP) reduction after RDN. Both randomized controlled trials and nonrandomized studies were included. We assessed the risk of bias using corresponding tools and further employed the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the overall quality of evidence. A total of 50 studies were ultimately included in this systematic review, among which 17 studies were for meta-analysis. Higher baseline heart rate and lower pulse wave velocity were shown to be associated with significant antihypertensive efficacy of RDN on 24-hour systolic BP reduction (weighted mean difference, -4.05 95% CI, -7.33 to -0.77; weighted mean difference, -7.20 95% CI, -9.79 to -4.62, respectively). In addition, based on qualitative analysis, higher baseline BP, orthostatic hypertension, impaired baroreflex sensitivity, and several biomarkers are also reported to be associated with significant BP reduction after RDN. CONCLUSIONS: In patients with hypertension treated with the RDN, higher heart rate, and lower pulse wave velocity were associated with significant BP reduction after RDN. Other factors, including higher baseline BP, hypertensive patients with orthostatic hypertension, BP variability, impaired cardiac baroreflex sensitivity, and some biomarkers are also reported to be associated with a better BP response to RDN.
Hu et al. (Tue,) conducted a meta-analysis in Hypertension. Renal denervation (RDN) was evaluated on Blood pressure (BP) reduction after RDN (WMD -4.05 (higher HR); WMD -7.20 (lower PWV), 95% CI -7.33 to -0.77 (higher HR); -9.79 to -4.62 (lower PWV)). Higher baseline heart rate and lower pulse wave velocity predicted significant 24-hour systolic BP reduction after renal denervation (WMD -4.05 and -7.20, respectively).