Key result
The presence of cardiovascular risk factors modified the relationship between systolic blood pressure and age in hypertensive subjects for both office and ambulatory measurements.
Why the study?
Blood pressure is affected by ageing and cardiovascular risk factors, but how risk factors modify the relationship between blood pressure and age in hypertensive and normotensive subjects required evaluation.
Does the presence of cardiovascular risk factors modify the relationship between age and blood pressure in hypertensive and normotensive subjects?
Observational (n=880)
No
Does the presence of cardiovascular risk factors modify the relationship between age and blood pressure in hypertensive and normotensive subjects?
Cardiovascular risk factors modify the age-related increase in systolic blood pressure, particularly in hypertensive patients.
Blood Pressure (BP) is a biological signal related to the cardiovascular system that inevitably is affected by ageing. Moreover, it is also influenced by the presence of cardiovascular risk factors. To evaluate how the relationship be-tween BP and age changes with the presence of risk factors in hypertensive and normotensive subjects, we analyzed 880 subjects with and without smoking, obe-sity, diabetes mellitus and dyslipidemia. A regression line fitted each BP/Age relation calculated separately for normotensive and hypertensive subjects with and without risk factors. For each of the four conditions the office and the 24-hour ambulatory BP monitoring (ABPM) were considered. In subjects with and without risk factors, the slopes of the Systolic BP/Age relation were higher in hypertensive than in normotensive subjects in both office and ABPM conditions. Moreover, the presence of risk factors modified the Systolic BP/Age relation in hypertensive subjects by using either office or ABPM measurements. Finally, we confirmed that the difference between the two modalities depends on age too.
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Silveri et al. (2020) conducted an observational in Known or suspected hypertension (n=880). Cardiovascular risk factors (smoking, obesity, diabetes mellitus, dyslipidemia) vs. Absence of cardiovascular risk factors was evaluated on Systolic Blood Pressure/Age relationship (slope). The presence of cardiovascular risk factors modified the relationship between systolic blood pressure and age in hypertensive subjects for both office and ambulatory measurements.
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