Key result
Aging with elevated BP is associated with declining cardiac index and rising systemic vascular resistance.
Why the study?
Little information existed on whether age serves as a good proxy for the specific hemodynamic profile of an individual with elevated BP, which could influence therapy selection.
Does age accurately indicate the hemodynamic profile (cardiac index and systemic vascular resistance index) in individuals with elevated blood pressure?
Population
45,082 individuals aged 20 to 80 years with elevated BP across 51 sites in China
Comparison
Relationship between age and hemodynamic parameters
Design
Multicenter cross-sectional study
Authors
Loading...
Age alone inadequately proxies individual hemodynamics in elevated BP due to within-strata heterogeneity; leaves open whether profiling improves risk stratification or therapy selection.
Cross-Sectional (n=45,082)
Yes
Does age accurately indicate the hemodynamic profile (cardiac index and systemic vascular resistance index) in individuals with elevated blood pressure?
Although cardiac index decreases and systemic vascular resistance increases with age in individuals with elevated blood pressure, substantial heterogeneity within age strata suggests age alone is an inadequate proxy for individual hemodynamic profiling.
Mahajan et al. (2020) conducted a cross-sectional in Elevated blood pressure (n=45,082). Age was evaluated on Relationship between age and hemodynamic parameters (cardiac index, systemic vascular resistance index [SVRI]). In individuals with elevated blood pressure, cardiac index decreased per decade by 0.17 L/min/m2 in men and 0.24 in women, while systemic vascular resistance index increased.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: