Key result
Non-contrast cine strain analysis correctly localizes ~50% more infarcted segments than visual wall motion assessment.
Why the study?
Due to concerns over gadolinium depositions and contraindications to contrast agents, the authors sought to evaluate whether non-contrast cine MRI segmental strain could detect chronic ischemic scars in CAD.
Does segmental strain analysis based on non-contrast cine images improve the detection of chronic ischemic scars compared to visual wall motion assessment in patients with known CAD?
Comparison
Segmental circumferential strain calculations vs visual wall motion assessment
Design
Retrospective case-control study with two independent blinded readers
Authors
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May aid non-contrast scar localization in gadolinium-contraindicated CAD patients; hypothesis-generating, requiring prospective validation before practice change.
Case-Control (n=70)
Double-blind
No
Does segmental strain analysis based on non-contrast cine images improve the detection of chronic ischemic scars compared to visual wall motion assessment in patients with known CAD?
Absolute Event Rate: 80.3% vs 53.7%
p-value: p=>0.01
Segmental circumferential strain analysis of non-contrast cine MRI significantly improves the detection of chronic ischemic scars compared to visual wall motion assessment, offering a viable alternative for patients who cannot receive gadolinium.
Polacin et al. (2021) conducted a case-control in Coronary artery disease with chronic ischemic scars (n=70). Segmental circumferential strain analysis on non-contrast cine images vs. Visual wall motion assessment was evaluated on Correct localization of infarcted segments compared to late gadolinium enhancement (p=>0.01). Segmental circumferential strain analysis based on non-contrast cine images correctly localized 80.3% of infarcted segments compared to 53.7% detected by visual wall motion assessment.
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