What does this research mean for the field?

Tumor necrosis factor (TNF) downregulates thrombomodulin on endothelial cells by inducing its internalization and subsequent degradation, a process that cannot be prevented by components of the protein C anticoagulant pathway. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1989BloodOpen Access

Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture

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Structured PICO

Population

Bovine aortic endothelial cells in culture

Intervention

Tumor necrosis factor (TNF) 2 nmol/L

Comparator

Control (untreated cells)

Outcome

Surface expressed thrombomodulin (TM) antigen and activity, and total TM poolsurrogate

TNF induces the internalization and subsequent degradation of thrombomodulin on endothelial cells, providing a mechanism for inflammation-induced prothrombotic shifts.

Discussion

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Implication

TNF-induced TM loss may heighten thrombotic risk in inflammation; leaves open human validation and therapeutic targeting.

Cite This Study

Moore et al. (1989) studied this question.

synapsesocial.com/papers/6a12be895bb7edc7189e3624 https://doi.org/10.1182/blood.v73.1.159.159

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Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture

Structured PICO

Discussion

Implication

Cite This Study

Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider