Thrombomodulin is expressed in brain microcirculation and its downregulation by cytokines may contribute to ischemic brain damage, which could potentially be counteracted by retinoic acid and cAMP.
No takes yet. Share an insight, caveat, or question.
Cytokine-driven TM downregulation may exacerbate ischemic brain injury in animals; hypothesis-generating for retinoic acid or cAMP modulation in humans.
Wang et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: