What question did this study set out to answer?

The aim is to explore the structure, functions, and clinical significance of thrombomodulin as a biomarker.

January 10, 2026Journal of Venous Disorders

Thrombotic Hazard Markers: Thrombomodulin

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Key result

Thrombomodulin shows potential as a blood biomarker for thrombosis risk despite low specificity.

Why the study?

Although thrombomodulin has established diagnostic and prognostic value, its clinical utility is limited by low specificity, prompting a review of its structure, functions, current clinical practice, and potential as a thrombosis risk marker.

Design

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Authors

MTM.M. TanashyanResearch Center of Neurology ERE. RoitmanPirogov Russian National Research Medical University ARA.A. RaskurazhevResearch Center of Neurology

Discussion

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Implication

TM biomarker potential merits prospective validation studies; low specificity precludes routine clinical adoption.

Key Points

The aim is to explore the structure, functions, and clinical significance of thrombomodulin as a biomarker.
Review of current literature on thrombomodulin's roles in coagulation and inflammation.
Analysis of therapeutic potentials in conditions like disseminated intravascular coagulation and preeclampsia.
Evaluation of the diagnostic and prognostic value of thrombomodulin in various diseases.
Thrombomodulin blood levels typically do not exceed 10 ng/mL in healthy individuals but can vary in abnormal conditions.
TM plays crucial roles beyond fibrinolysis, including inflammation and neuroprotection.
Diagnostic utility of TM is limited by low specificity, but its clinical application indicates potential for further investigation.

Cite This Study

Tanashyan et al. (2025) studied this question. Thrombomodulin (TM) exhibits multimodal properties and holds potential as a blood biomarker for thrombosis risk despite its low specificity.

synapsesocial.com/papers/6963221b91e05aa366cb8995 https://doi.org/10.17116/flebo202519041296

Topics

Pulmonary embolism

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Thrombotic Hazard Markers: Thrombomodulin

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Implication

Key Points

Cite This Study

Topics

Thrombotic Hazard Markers: Thrombomodulin

Discussion

Member takes

Implication

Key Points

Cite This Study

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