Key result
Thrombomodulin dysfunction leads to various hemostatic and inflammatory disorders, while recombinant thrombomodulin shows potential as a diagnostic marker and therapeutic agent for conditions like DIC and atypical HUS.
Why the study?
Studying clinical manifestations of thrombomodulin dysfunction helps to better understand its role in physiological processes and develop new treatment strategies.
This review summarizes the genetic mutations of thrombomodulin, their clinical manifestations, and the diagnostic and therapeutic potential of recombinant thrombomodulin in various conditions.
Recombinant thrombomodulin merits exploration in pediatric DIC and aHUS; current Level 5 evidence leaves its diagnostic and therapeutic roles open.
Thrombomodulin (TM) performs a wide variety of functions: it is involved in the regulation of hemostatic answer, inflammation, cell proliferation and angiogenesis. Studying clinical manifestations of thrombomodulin dysfunction helps to better understand its role in various physiological processes and develop new treatment strategies involving the use of thrombomodulin. Here, we focused on genetic causes of this problem, describing some pathological mutations in the TM gene as well as their clinical manifestations. We also reported on TM use in disease diagnosis and treatment and discussed the prospects for its application in the management of various life-threatening conditions.
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Bleskin et al. (2024) conducted a review in Thrombomodulin dysfunction. Thrombomodulin and recombinant thrombomodulin was evaluated. Thrombomodulin dysfunction leads to various hemostatic and inflammatory disorders, while recombinant thrombomodulin shows potential as a diagnostic marker and therapeutic agent for conditions like DIC and atypical HUS.
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